Non-convulsive status epilepticus: Electro-clinical features, and prognosis in a developing country, Mexico
Abstract number :
1.388
Submission category :
Camelice Poster
Year :
2021
Submission ID :
1886408
Source :
www.aesnet.org
Presentation date :
12/9/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Jacob García Torres, MD - National Institute of Neurology and Neurosurgery; Daniel San Juan Orta, MD – Clinical researcher, Epilepsy Clinic, National Institute of Neurology and Neurosurgery; Erick Bautista Ángeles, MD – Clinical researcher, Neurophysiology Clinic, National Institute of Neurology and Neurosurgery; María Fernández González-Aragón, MD – Clinical researcher, Neurophysiology Clinic, National Institute of Neurology and Neurosurgery; Ángel Labra Lorenzana, MD – Social Service, Epilepsy Clinic, National Institute of Neurology and Neurosurgery; Carlos Trenado, PhD – Clinical researcher, Düsseldorf and Systems Neuroscience and Neurotechnology Unit, Heinrich-Heine-University
Rationale: There is a lack of clinical and epidemiological knowledge about the non-convulsive status epilepticus (NCSE) in developing countries. Mexico had the highest prevalence of epilepsy in Latin America and it is urgent to know this information. The aim of the study is to describe the electro-clinical findings and outcomes of NCSE in a third-level center in Mexico.
Methods: We conducted a retrospective case-series study (2010-2020) that included 134 patients (≥ 15 years old) with NCSE according to the modified Salzburg NCSE criteria 2015 with at least 6 months of follow-up. We extracted clinical data (age, sex, history of epilepsy, antiseizures medications, clinical manifestations, triggers, and etiology), EEG patterns of NCSE and outcome. Descriptive statistics and multinomial logistic regression were used. The study was approved by the Research and Ethics and Investigation Committees INNN No. 126/20.
Results: 134 patients were analyzed; 55% females, mean total age was 39.5 years and 70% had a history of epilepsy. Altered state of consciousness was found in 82% (including 27.7% in coma) followed by neuropsychiatric manifestations in 5.2%. The generalized NCSE pattern was the most common (32.1%). The NCSE etiology was mainly idiopathic (56%), followed by neuro-infection in 22.4%; and previous uncontrolled epilepsy was the trigger in 58% of patients. The clinical outcome was remission with clinical improvement in 54.5%. Multinomial logistic regression showed that the patient's age (p=0.04), absence of comorbidities (p=0.04), history of perinatal hypoxia (p=0.04), absence of clinical manifestations (p=0.01), coma (p=0.03), and absence of generalized slowing in the EEG (p=0.001) have a significant effect on the prognosis (p < 0,001).
Camelice Poster