Non Invasive Deep Brain Stimulation via Temporal Interference Decrease Epileptic Spiking Activity in Patient
Abstract number :
3.089
Submission category :
2. Translational Research / 2A. Human Studies
Year :
2022
Submission ID :
2204661
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:26 AM
Authors :
Emma ACERBO, MS – Institut de Neurosciences des systemes; Aude Jegou, MS – Institut de neurosciences des systemes; Boris Botzanowski, MS – Institut de neurosciences des systemes; Ibrahima Ngom, MS – Institut de neurosciences des systemes; Florian Missey, MS – Institut de neurosciences des systemes; Stanislas Lagarde, MD, PhD – Institut de neurosciences des systemes; Fabrice Bartolomei, MD, PhD – Institut de neurosciences des systemes; Viktor Jirsa, PhD – Institut de neurosciences des systemes; Adam Williamson, PhD – Institut de neurosciences des systemes
Rationale: Electrical stimulation as a neuromodulation method in epilepsy has been increasingly explored and included in clinical therapy. Recently, a new method of non-invasive brain stimulation was described by Grossman et al., the temporal interference (TI). It is based on the application of two high-frequency electric fields (>1 KHz, f1 and f2) via two pairs extra-cranial electrode.1 The superposition generates a low-frequency stimulation (Δf) envelope which allow to stimulate a deep precise brain area. We previously demonstrated that applied on mice hippocampus, a TI stimulation at Δf =130Hz (f1=1300 Hz, f2=1430 Hz) was able to decrease the number of fast ripples and inter-ictal spikes.2 Thus, we wanted to test this protocol on patients with temporal lobe epilepsy in order to see if we can recreate the anti-epileptic effect.
Methods: Patients underwent insertion of intracerebral multiple contact electrodes (Alcis, France) for SEEG exploration. Because of their epilepsy, patients had hippocampal sampling as part of their routine care and also an CT post operative. SEEG signal was recorded on a digital system (Natus Medical Incorporated) with sampling at 1024 Hz or more with 16- bit resolution, a hardware high- pass filter (cutoff = .16 Hz), and an antialiasing low- pass filter (cutoff = 340 Hz). Patients were awake and electrodes of stimulation were placed on the skin to target one of the hippocampus following coordinates given by simulation. Baseline recording were done for 20min and TI stimulation was turn on for 20 minutes too. Interictal spikes rate and features (Duration, Amplitude and Area of the wave) were analysed to asses the impact of the TI stimulation.
Results: A decrease by 2 in the number of epileptic spikes was observed during the stimulation (Before vs. stim: p-value < 0.001 – STIM vs. Post: p-value = 0.0018 – Before vs. Post : p-value = 0.275). Also, TI-HFS decreased all the spikes’ features (Area: Before vs. STIM: p-value < 0.001, Before vs. Post: p-value = 0.946, STIM vs. Post: p-value = 0.051 - Amplitude: Before vs. STIM: p-value= 0.006, Before vs. Post : p-value = 0.273 STIM vs. Post: p-value = 0.02 - Duration: Before vs. STIM: p-value < 0.001, Before vs. Post : p-value = 0.54 STIM vs. Post: p-value < 0.001).
Translational Research