Patient Reported Quality of Life Before and After Insular Resection for Patients with Epilepsy
Abstract number :
2.151
Submission category :
4. Clinical Epilepsy / 4D. Prognosis
Year :
2022
Submission ID :
2205062
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:27 AM
Authors :
Mostafa Fatehi Hassanabad, MD, MSc, FRCSC – University of British Columbia; Sandra Wahby, MSc – University of Calgary; Colin Josephson, MD, MSc, FRCPC – University of Calgary; Paolo Fredrico, MD, PhD, FRCPC – Clinical Neurosciences – University of Calgary; Samuel Weibe, MD, FRCPC – University of Calgary; Walter Hader, MD, MSc, FRCSC – Clinical Neurosciences – University of Calgary
Rationale: Advances in characterizing the semiology of seizures arising within the insula have provided the impetus for renewed interest in insular resections for patients with intractable epilepsy. Despite, the increasing frequency of these procedures, the impact on patient-reported quality of life is poorly studied.
Methods: Using an institutional database of patients undergoing surgery for epilepsy, we assessed the rate of seizure freedom and any post-operative deficits. We also collected pre- and post-operative patient reported quality of life (QoL) using validated questionnaire. The results of this cohort were compared with an age- and gender-matched cohort of patients who underwent temporal lobectomies.
Results: Between 2011 and 2021, 15 adult patients underwent insular resections of whom 13 had completed the QoL surveys before and after surgery. After a mean follow-up of 19 months, 62% achieved seizure freedom and 14% had persistent deficits. Improvements were reported across various domains of QoL, especially in social limitations. Patients also reported a high rate of depression before and after the surgery.
Conclusions: The improvements observed across various QoL domains after surgery are significantly greater than those seen in patients undergoing temporal lobectomy for epilepsy.
Funding: None
Clinical Epilepsy