Abstracts

Peri-ictal Neuropsychiatric Symptoms in Patients with Epilepsy Associated with Breakthrough Seizures in a Specialized Neurological Emergencies Center Setting

Abstract number : 3.424
Submission category : 6. Cormorbidity (Somatic and Psychiatric)
Year : 2023
Submission ID : 1408
Source : www.aesnet.org
Presentation date : 12/4/2023 12:00:00 AM
Published date :

Authors :
Presenting Author: Elma Paredes-Aragon, MD – National Institute of Neurology and Neurosurgery

Omar Delgado-Martinez, Medical student – Medical student, Department of Neurological Education and Training, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., National Institute of Neurology and Neurosurgery; Beatriz Epitacio-Neri, Medical student – Medical student, Department of Cardiology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., National Institute of Neurology and Neurosurgery; Jonathan Macías-López, Medical student – Medical student, Department of Neurological Emergencies, National Institute of Neurology and Neurosurgery, Mexico City, Mexico, National Institute of Neurology and Neurosurgery; Juan Carlos López-Hernández, MD – Neurologist, Department of Neurological Emergencies, National Institute of Neurology and Neurosurgery, Mexico City, Mexico, National Institute of Neurology and Neurosurgery; Mario Solis-Solis, Engineer – Engineer, Department of Neurological Education and Training, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., National Institute of Neurology and Neurosurgery; Ramiro Ruiz- García, MD – Neuropsychiatrist, Department of Neurological Education and Training, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., National Institute of Neurology and Neurosurgery

Rationale:
Premorbid psychiatric symptoms (PPS) increase the risk of developing epilepsy. Neuropsychiatric manifestations occur in 20-40% of PWE (patients with epilepsy) during the peri-ictal period (NPsPI). Clinical phenomena and outcomes are poorly understood in PWE and NPsPI. Our study sought to clinically describe PPS and NPsPI, identify trends and correlation between these patients and the presence of breakthrough seizures (BSz) in follow-up in a third-level specialized neurological center emergency department (ED).

Methods:
A retrospective analysis was performed using an in-house general Redcap database of all patients seen in the ED at our center. Demographic characteristics (Table1) were done with standard deviation and frequencies. PWE were divided into first admission with BSz (1BSz), and patients that re-visited the ED with BSz (2Bsz). To evaluate neuropsychiatric manifestations, the Neuropsychiatric Inventory (NPI) was utilized. Chi-square tests and t-tests were used for descriptive and association statistics, additionally a survival analysis was performed including psychiatric manifestations and follow-up BSz.

Results:
A total of 264 PWE were recruited from January through September 2023. Demographic clinical findings are included in Table 1. Significant associations for readmission were seen for age (t= -2.56 p<
Cormorbidity (Somatic and Psychiatric)