Periodic Patterns Characteristics in Patients with Brain Tumor and Their Association with Status Epilepticus (SE): A Retrospective Study
Abstract number :
2.134
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2024
Submission ID :
1139
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Stefano Consoli, MD – Department of Neuroscience Imaging and Clinical Sciences "G. d’Annunzio” University of Chieti-Pescara
Fedele Dono, MD, MSc, cPHD, FEBN – Deparment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara
Giacomo Evangelista, MD, cPhD – Department of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, Italy
Clarissa Corniello, MD – Department of Neuroscience Imaging and Clinical Sciences "G. d’Annunzio” University of Chieti-Pescara
Sara Cipollone, MD – Department of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, Italy
Sibilla De Angelis, MD – University “G. D’Annunzio” of Chieti-Pescara
Davide Liviello, MD – Department of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, Italy
Paolo Quintieri, MD – Department of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, Italy
Stefano Sensi, MD, PhD – 'G. D'Annunzio' University of Chieti Pescara
Rationale: Periodic discharges (PDs) represent an EEG pattern commonly found in association with focal cerebral lesions, particularly brain tumors (BT). The clinical interpretation of PDs is controversial as well as their pathophysiological origin. This study aims to describe the prevalence and characteristics of PDs in patients with BT, focusing on their association with epilepsy diagnosis and status epilepticus (SE).
Methods: Adult patients suffering from primary BT who underwent a video-EEG recording were retrospectively selected from the Neurology Clinic of "G. d'Annunzio" University of Chieti-Pescara from January 2016 to January 2024. Demographics, clinical features, as well as tumor characteristics, and radiological findings, were collected. Video-EEG data were reviewed to identify patients with PDs. Diagnosis of epilepsy and SE were made according to ILAE criteria.
Results: 140 patients (mean age 60.6; 61 females) were enrolled. Fifteen patients (10.7%) showed PDs at video-EEG. Patients with PDs presented lateralized PDs (LPDs) in most cases (93.3%), with a mean frequency of 1 Hz and temporal lobe localization in 73.3%, concordant with the tumor lesion side in 73.3% of the cases. Eleven (73.3%) patients suffered from epilepsy, whereas SE was described in four (26.7%) patients, associated with a higher PD frequency (1.5 Hz vs 0.8 Hz). Comparing primary BT with and without PDs, patients with PDs presented more often a parieto-occipital lesion localization (p=0.01) and high-grade histology (p=0.01). No differences were observed according to sex, age, number of EEG performed, lesion dimension, and tumor lateralization.
Conclusions: PDs can be more frequently observed in high-grade primary BT with parieto-occipital localization. PDs are highly associated with the diagnosis of epilepsy. In patients with HGG a PD frequency > 1.5 Hz is highly suggestive of an ictal pattern and should be promptly treated.
Funding: None
Neurophysiology