Phenomenological Differences Between Epileptic Seizures, Sleep Dreams and Wakefulness Epochs Captured in Patients with Intracranial Recordings
Abstract number :
3.13
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2023
Submission ID :
1144
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
First Author: Maximilian Grobbelaar, BS. – UW Madison
Presenting Author: Urszula Gorska-Klimowska, PhD. – UW Madison
Marek Solvik, BS. – UW Madison; Cameron Brace, BS. – UW-Madison; Urszula Gorska-Klimowska, PhD. – UW Madison; Csaba Kozma, MS. – UW Madison; Tariq Allaudin, BS. – UW Madison; Jenna Fawcet, Ms – UW Madison; Isabelle Bednorski, Ms – UW Madison; Sean Prahl, Mr – UW Madison; Javeria Azam, Ms – UW Madison; Aubrey Berther, Ms – UW Madison; Hannah Holmes, Ms – UW Madison; Griffin Scott Gleisner, Mr – UW Madison; Giulio Tononi, MD. PhD. – UW Madison; Melanie Boly, MD. PhD. – UW Madison
Rationale: Focal epilepsy is a life-long neurological disorder, with up to 40% of patients having poor treatment control. Recent data suggest that poorer treatment outcomes are often observed in patients who have had ongoing seizures for many years. While most patients are only referred to neurology clinics after the occurrence of seizures with impaired consciousness, they typically report that they experienced non-motor auras for several years before. Thus, the development of a screening tool for epileptic auras as compared to non-epileptic events may help to facilitate earlier referrals. By systematically quantifying differences in dimensions of subjective experiences during seizures, sleep dreams and wakefulness, we aimed to identify experiential patterns that may serve as screening tools for epileptic auras in ambulatory studies.
Methods: We collected subjective reports in epileptic patients admitted for clinical intracranial recordings in the UW-Hospital Epilepsy Monitoring Unit using systematic questionnaires administered 1) just after seizures, 2) just after awakening from sleep, or 3) during wake. The questionnaires sampled alterations in self vs environment perception, as well as emotions. Second-person ratings by observed blinded to ictal vs interictal conditions included bodily and narrative self, metacognition, bizarreness, and autobiographical planning. Analysis used a linear mixed effects approach comparing these phenomenological dimensions across conditions with results thresholded at p< 0.05 corrected for multiple comparisons using false discovery rate.
Neurophysiology