Prediction and Correlation of Seizures Following Pediatric Traumatic Brain Injury
Abstract number :
2.177
Submission category :
4. Clinical Epilepsy / 4D. Prognosis
Year :
2023
Submission ID :
623
Source :
www.aesnet.org
Presentation date :
12/3/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Chungmo Koo, MD – Dankook University College of Medicine
Yoon Soo Kim, MD – Department of Pediatrics, Dankook University College of Medicine; In-Ho Jung, MD – Department of Neurosurgery, Dankook University College of Medicine; Sang-Koo Lee, MD – Department of Neurosurgery, Dankook University College of Medicine; Jeesuk Yu, MD – Dankook University College of Medicine
Rationale:
In pediatric patients, Traumatic Brain Injury (TBI) may result in severe complications, including mortality and cognitive impairment. Post-Traumatic Seizures (PTS) can potentially cause secondary cerebral damage due to increased brain metabolism and elevated intracranial pressure. As such, predicting and proactively addressing PTS is a crucial component of TBI management in children.
Methods:
We conducted a retrospective study on 58 pediatric patients (< 18 years old) hospitalized and treated for TBI at Dankook University Hospital in Korea from 2018 to 2021.
Results:
Among the TBI patients in our study, twelve (20.7%) exhibited PTS, with nine (75%) of these cases presenting as early PTS within seven days following the traumatic event. Factors associated with the occurrence of PTS included age at the time of trauma (p=0.034), mechanism of trauma (p=0.013), presence of subdural hemorrhage (p=0.008), and a Pediatric Trauma Score below eight indicating severe trauma (p=0.038). Initial measurements of pH, Base Excess (BE), and lactate levels in TBI patients did not demonstrate a statistically significant association with the occurrence of PTS. However, further analysis revealed a statistically significant correlation between the onset of PTS and BE (p=0.015, r=0.739) among PTS patients. Additionally, both BE (p< 0.001) and lactate levels (p=0.042) were found to be factors influencing the onset of PTS; as these values decreased, the onset time of PTS was observed to advance.
Conclusions:
Through this study, we anticipate that early measurements of BE and lactate levels following traumatic events may help predict the onset of PTS in acute pediatric TBI patients.
Funding:
This study did not receive any grants.
Clinical Epilepsy