Prevention of Early Seizures after Brain Surgery: A Placebo-Controlled Comparison of Levetiracetam with Oxcarbazepine
Abstract number :
4.156
Submission category :
Surgery-Adult
Year :
2006
Submission ID :
7045
Source :
www.aesnet.org
Presentation date :
12/1/2006 12:00:00 AM
Published date :
Nov 30, 2006, 06:00 AM
Authors :
Addolorata Mascia, Antonio Sparano, Vincenzo Esposito, Sergio Paolini, Roberta Morace, Giancarlo Di Gennaro, and Pier Paolo Quarato
To determine the potential effectiveness and tolerability of levitiracetam (Lev) versus oxacarbazepine (Oxc) versus placebo in preventing early postoperative seizures in patients undergoing brain surgery for mass lesions., 30 patients requiring elective craniotomy for supratentorial brain mass lesions were randomized to three groups of equal size, with a prospective, open-label, controlled design.
One group receveid Lev (13.3-40 mg/kg/die) the other group receveid Oxc (18-20 mg/kg/die), the third group receveid placebo. In all the three groups the drug administration were oral with a titration performed within the 30 days preceding surgery. Early postoperative seizures (seizures occurring in the 7 days following surgery) were considered for the purpose of the study.
Patients having chronic epilepsy were not included. On the contrary, heralding seizures were not considered as esclusion criterion, Early post-operative seizures were observed in all three groups. Patients taking Lev or Oxc showed less seizures than patients taking placebo., In our study Lev and Oxc seemed to be similarly effective in preventing early seizures after brain surgery. Both the drugs showed a good profile of tolerability and all patients remaining on each treatment during all the duration of the study.,
Surgery