Retrospective Evaluation of Interictal Cardiac Biomarkers in People Succumbing to SUDEP or Near-sudep
Abstract number :
2.107
Submission category :
3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year :
2024
Submission ID :
1042
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Charles Szabo, MD – UT Health San Antonio/South Texas Comprehensive Epilepsy Center
Asra Tanwir, MD – Mayo Clinic
Amy Werry-McFarlin, PhD – UT Health San Antonio
Alejandra Duque Ramirez, MD – UT Health San Anotnio
Rationale: Heart rate variability (HRV) and QTc-interval changes are reported in people succumbing to sudden unexpected death in epilepsy (SUDEP). We evaluated the interictal cardiac biomarkers recorded during Video-EEG monitoring in eight SUDEP cases and one near-SUDEP case and compared them to 9 age- and gender-matched people with psychogenic nonepileptic spells (PNES) but treated with antiseizure medications (ASMs). We compared differences in HRV, heart rate (HR) and QTc-intervals and their change between the groups over the course of their admission.
Methods: Artifact-free awake and sleep EEG samples were identified during the first and last 24- hour periods of video-EEG recordings. Ten consecutive QT-intervals and a 60-second sample of RR-intervals were measured. The Fridericia correction was used QT-interval duration (QTcF) measurements and root mean squares of successive differences between normal heartbeats (RMSSD) were calculated for HRV. Baseline values and their change between measurements were compared between the SUDEP and PNES groups (two-tailed T-tests, alpha< 0.05).
Neurophysiology