Syndrome Specific Functional Imaging Traits in Juvenile Myoclonic and Absence Epilepsy
Abstract number :
2.187
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2022
Submission ID :
2204341
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
Fenglai Xiao, MD PhD – UCL; Lorenzo Caciagli, MD PhD – Department of Engineering – PENN; Maria Centeno, MD PhD – UCL/Hospital clinic of Barcelona; Christian Vollmar, MD PhD – UCL/ University of Munich; Karin Trimmel, MD PhD – UCL; Luisa Delazer, MBBS – UCL; John Duncan, MD PhD – UCL; Matthias Koepp, MD PhD – UCL; Britta Wndschneider, MD PhD – UCL
Rationale: Juvenile absence epilepsy (JAE) and juvenile myclonic epilepsy (JME) are highly heritable idiophathic generalised epilepsy( IGE) syndromes. Employing a functional (fMRI) working memory study, we previously demonstrated abnormal motor coactivation during with increasing cognitive demand in JME and their healthy siblings, suggestive of a genetically determined, functional imaging trait (Vollmar et al., 2011; Wandschneider et al., 2014). To determine whether this trait is JME syndrome specific, we employed the same task in JAE patients and their unaffected siblings. _x000D_
Methods: We employed a visual-spatial fMRI working memory task (dot back task) in 20 patients with JAE, 18 unaffected siblings and 27 age and sex matched healthy controls. The exploratory threshold is set at p< 0.005, 30 voxels.
Neuro Imaging