The Relationship Between the Metabolic Signals of the Brain FDG-PET and the Cognitive Function in Mesial Temporal Epilepsy
Abstract number :
2.158
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2021
Submission ID :
1826194
Source :
www.aesnet.org
Presentation date :
12/5/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:53 AM
Authors :
Syu-Jyun Peng, PhD - Taipei Medical Universality; Hsin Tung - Taichung Veterans General Hospital
Rationale: Brain 18F-labeled fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a commonly used metabolic image, applying for the neurodegenerative diseases, including dementia and epilepsy. PET had been used for epileptogenic zone localization, which usually presented hypometabolic signal. However, whether the metabolic signal of any brain region is associated with the cognitive function has not been identified.
Methods: We collected the brain FDG-PET imaging from 26 mesial temporal lobe epilepsy (MTLE) patients (right-MTLE: 13, left-MTLE: 13) and 13 matched controls in 2019.
The FDG PET images were spatially normalized to the MNI atlas using the software toolkit Statistical Parametric Mapping 12. The average standardized uptake values (SUV) values of the pons were used as the reference, which applied for normalizing the SUV of the whole brain. Subsequently, we conducted spatial smoothing with an 8mm full width at half maximum Gaussian kernel. The SUV values of the left-MTLE and right-MTLE cases were voxel-by-voxel compared with the values of the controls. Then, the voxel-based analysis was conducted to establish the relationship between SUV and the individual seizure duration, intelligence quotient (full IQ, verbal IQ, performance IQ), working memory, and processing speed index. P < 0.01 was thought as significance.
Neuro Imaging