Transcranial Alternating Current Stimulation: A potential risk for primary generalized epilepsy patients (Study Case)
Abstract number :
2.377
Submission category :
18. Case Studies
Year :
2016
Submission ID :
227014
Source :
www.aesnet.org
Presentation date :
12/4/2016 12:00:00 AM
Published date :
Nov 21, 2016, 18:00 PM
Authors :
Axel Hernandez-Ruiz, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Daniel San-Juan, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Carlos I. Sarmiento, National Institute of Neurology and Neurosurgery, Mexi
Rationale: Transcranial alternating current stimulation (tACS) ia a neuromodulation technique that consists in the external application of oscillating electrical currents that induce changes generalized in cortical excitability. We report a 16 year-old female with juvenile myoclonic pharmaco-resistant epilepsy showing before the intervention four myoclonic and 20 absence seizures monthly. Methods: The patient received a 1mA@3Hz pulse train during 60 minutes over Fp1-Fp2 (10-20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device® (Natus Medical Incorporated, Middleton, WI, USA) as stimulator. Results: One month after the stimulation, she reported a 75% increase in seizures frequency and she had a myoclonic status epilepticus, controlled with oral clonazepam and intravenous valproate. Two months after the stimulation, the patient reported a 15-day seizures-free period. Conclusions: To our knowledge, this is the first case reported using this neuromodulation approach. We suggest that future clinical trials using tACS should use >10Hz frequencies to modulate cortical activity between directly stimulated areas and more distant but anatomically and functionally connected regions. Funding: No funding was received in support of this abstract.
Case Studies