Abstracts

Rationale: Acquired aphasia with electroencephalogram (EEG) abnormality is a rare disease so there are a few studies for prognostic factors and treatment efficiency. We sought to determine the therapeutic effect and prognostic factors for clinical seizure and neuropsychological function in these patients. Methods: We retrospectively studied acquired aphasia with more than 85% spike and wave during sleep (SWS) diagnosed at Severance Children's Hospital from January 2013 to October 2017. The efficacy of valproate (VPA), levetiracetam (LEV), steroids, and ketogenic diets (KD) were evaluated and the EEG and prognostic factors were predicted by the background of EEG. Results: The proportion of patients studied was 9 in males and 7 in females and acquired aphasia most commonly occurred at 4 years of age. And 2 to 4 years of age were the most common periods of clinical seizures. The frequency of SWS on EEG was more than 85% and focal type was the most frequent. KD was the best treatment for a clinical seizure of acquired aphasia patients. Patients with normal EEG background showed the better response to treatment of clinical seizure and of neuropsychological function. In patients with delayed neuropsychological function, that was not improved in generalized slowing on EEG background and generalized CSWS pattern on EEG. Conclusions: KD and steroids show the best therapeutic effect for clinical seizure in acquired aphasia patients. In patients with acquired aphasia, the neuropsychological function and its improvement may be related to the background of the EEG and its association with the pattern of CSWS. The response of the clinical seizure to the AED can also be considered in relation to the background of the EEG. This study has some limitations and further research is needed in the future. Funding: None