VOLUMETRIC EVIDENCE OF CONTRALATERAL DAMAGE IN UNILATERAL MESIAL TEMPORAL LOBE EPILEPSY
Abstract number :
1.206
Submission category :
Year :
2003
Submission ID :
3750
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
David Araujo, Tonicarlo Rodrigues Velasco, Lauro Wichert-Ana, Veriano Alexandre, Jr., Vera Cristina Terra Bustamante, Roger Walz, Antonio Gilberto Carlotti, Jr., Joao Antonio Assirati, Jr., Americo Ceiki Sakamoto, Antonio Carlos Santos, Joao Pereira Leite
There is increasing evidence that temporal lobe epilepsy (TLE) may be related to widespread changes, involving extrahippocampal and contralateral structures. In our paper we investigated the pre-surgical contralateral mean volumes of hippocampus, amygdala, temporal pole, parahippocampal gyrus, and posterior segment of the temporal lobe in unilateral TLE patients.
Sixty-nine consecutive patients and 23 normal controls were analyzed with MRI volumetry. All patients came from the Epilepsy Surgery of the Ribeir[atilde]o Preto Medical School, and were operated by anterior temporal lobectomy with adequate resection of mesial and neocortical structures, after comprehensive pre-surgical evaluation. All patients had mesial temporal sclerosis (MTS) by pathological examination.
Our data show significant difference of the mean volumes of temporal pole, parahippocampal gyrus, and hippocampus (p [lt] 0.05) between patients operated on the left or right side and controls. There was no difference between the mean volumes of amygdala and the posterior segment of the temporal lobe.
MRI volumetric data shows that damage in TLE due to MTS may be more widespread and, even in patients with unilateral TLE by clinical and neurophysiological criteria.