Brain network reconstruction of abnormal functional connectivity in Lennox-Gastaut syndrome according to drug responsiveness
Abstract number :
2.395
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2021
Submission ID :
1886434
Source :
www.aesnet.org
Presentation date :
12/5/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Yun Jung Hur, MD - Haeundae Paik hospital, Inje University College of Medicine; Kang Min Park, md – Haeundae Paik hospital, Inje University College of Medicine
Rationale: Lennox-Gastaut syndrome (LGS) shows abnormal functional connectivity. This study aimed to clarify whether the drug responsiveness in LGS could alter the network reconstruction of brain connectivity by comparing LGS with healthy control.
Methods: Thirty-seven patients with LGS and forty healthy controls were enrolled in this study. Patients with LGS were classified into drug-unresponsive LGS and drug-responsive groups. The graphic theoretical analysis was applied to reveal brain connectivity using resting-electroencephalography (EEG). Follow-up EEG was obtained in only 24 patients with LGS (drug responsive: drug unresponsive=13:11). The various network parameters of brain connectivity are investigated between each group.
Results: Network measurements were statistically significant between patients with LGS and healthy controls. In both frontal areas in patients with LGS, betweenness centrality was significantly reduced compared to healthy controls. The differences between the drug responsive and the unresponsive LGS groups were not significant in brain connectivity using the initial EEG. The drug-unresponsive LGS group (n=11) showed enhanced local and global connectivity by comparing the initial with the follow-up EEG. The drug-responsive LGS group (n=13) had no significant difference in brain connectivity between the initial and follow-up EEG. Compared with healthy controls, the drug-unresponsive LGS group showed enhanced local and global connectivity, while the drug-responsive LGS group showed no difference from healthy controls.
Conclusions: LGS patients tend to have different brain connectivity compared to healthy controls, and their hubs are decreased in the frontal areas. The brain connectivity of drug responsive LGS preserves the network reconstruction of brain connections to direct to a pattern similar to a healthy control group.
Funding: Please list any funding that was received in support of this abstract.: No.
Neurophysiology