Distribution of Auditory and Visual Naming Sites Identified with Stereo-eeg Electrodes
Abstract number :
1.356
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2022
Submission ID :
2204226
Source :
www.aesnet.org
Presentation date :
12/3/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
Lauren Goedde, BA – Columbia University Medical Center; Andrew Michalak, MD – Columbia University Medical Center; Alexander Agopyan-Miu, MD – Columbia University Medical Center; Guy McKhann, MD – Columbia University Medical Center; Brett Youngerman, MD – Columbia University Medical Center; Neil Feldstein, MD – Columbia University Medical Center; Catherine Schevon, MD, PhD – Columbia University Medical Center; Marla Hamberger, PhD – Columbia University Medical Center
Rationale: It is well established that the temporal lobe plays an essential role in naming, and cortical mapping studies have identified critical naming sites in the lateral temporal cortex. Our previous work has shown that stimulation of anterior temporal lateral cortex tends to disrupt auditory description naming (AN), but not visual object naming (VN), while the posterior lateral temporal stimulation tends to disrupt both auditory naming and visual naming. With the increasing use of stereo EEG (sEEG) for seizure localization, the use of sEEG stimulation to identify essential language areas has increased as well. However, the distribution of AN and VN sites beneath the lateral temporal surface is not yet known. We hypothesized that the distribution of auditory and visual naming sites would follow the same anterior vs. posterior distribution found cortically via subdural electrode and direct cortical stimulation.
Methods: Participants were 18 patients (8 women) who underwent stimulation-based extra-operative sEEG language mapping prior to surgical treatment of refractory left hemisphere epilepsy (age: 27.5 ± 12.3, FSIQ: 94.2 ± 17.8). The AN task requires patients to name items based on orally presented descriptions (e.g. “What a king wears on his head”), whereas VN requires naming of pictured objects. Both naming tasks were administered at each site tested during stimulation, with sites categorized as “AN” if stimulation disrupted AN only and “VN” if stimulation disrupted visual naming (either exclusively or with AN as well). The location of positive naming sites were determined to be “anterior” or “posterior” using the uncal apex (y = -21mm) to mark the anterior-posterior division. Pre-implant MRIs and post-implant CTs were co-registered and processed to determine the anatomical locations and MNI-152 coordinates of the electrodes. Site classification was assessed using Fisher’s exact test. The locations for AN and VN sites were compared using the MNI y-coordinates via independent samples t-test.
Results: Of the 18 patients, 15 had positive naming sites identified, with 26 positive naming sites identified across patients: 6 pure AN sites and 20 VN sites. The mean y-coordinate for AN sites was -9.8mm (20.8), and for VN sites was -26.7mm (20.9), following the predicted pattern of AN sites located anterior to VN sites (p = 0.09). Of the 6 AN sites, 5 were anterior, and 1 was posterior; whereas of the 20 VN sites, 8 were anterior, and 12 were posterior (Fisher’s Exact: p = 0.08).
Conclusions: These preliminary results suggest that the lateral temporal anterior-posterior distribution of AN and VN sites is likely maintained beneath the lateral cortical surface. Although a larger sample is needed to determine the reliability of this finding, results obtained thus far support the use of both AN and VN tasks in stimulation-based sEEG mapping to ensure identification of critical language sites.
Funding: NIH NINDS R01 NS035140
Behavior